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Alprazolam is in a class of medications called benzodiazepines. If a decision is made to prescribe XANAX XR concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. Store at controlled room temperature, 20 to 25C (68 to 77F) [see USP]. you are taking antifungal medicines including ketoconazole and itraconazole, have or have had depression, mood problems, or suicidal thoughts or behavior. Highly recommend Pharmacy. An extended-release drug is released slowly into the bloodstream over time. You may report side effects to FDA at 1-800-FDA-1088. Both types of white Xanax pills are manufactured by Pfizer. The mean T1/2 of alprazolam was 16.3 hours (range: 9.0 to 26.9 hours) in healthy elderly subjects compared to 11.0 hours (range: 6.3 to 15.8 hours, n=16) in healthy adult subjects. If you take too much XANAX XR, call your healthcare provider or go to the nearest hospital emergency room right away. Drowsiness WebXanax Pfizer 2mg. Other studied drugs include: Cimetidine: Coadministration of cimetidine increased the maximum plasma concentration of alprazolam by 82%, decreased clearance by 42%, and increased T1/2 by 16%. There are reports of sedation and withdrawal symptoms in breastfed neonates and infants exposed to alprazolam. Before prescribing XANAX and throughout treatment, assess each patients risk for abuse, misuse, and addiction. XANAX XR- alprazolamtablet, extended releasePharmacia & Upjohn Company LLC, XANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. In order to better understand the underground market for this drug, StreetRx collects data on the street price of Xanax and has found that its average black-market price is approximately $7. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. XANAX XR U.S. Xanax is a brand-name pill that contains alprazolam. The PfizerBioNTech COVID-19 vaccine (tozinameran), sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German company BioNTech. Alprazolam is 80% bound to human serum protein, and albumin accounts for the majority of the binding. WebXANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. Intravenous fluids should be administered and an adequate airway maintained. In some cases, they may not be available in every strength or form as the brand-name version. Recommended starting oral dosage is 0.5 mg to 1 mg once daily (preferably in the morning). DOSAGE AND USE: See accompanying prescribing information. As of 30 March 2021, Pfizer and BioNTech aimed to manufacture about 2.5billion doses in 2021. Talk to your healthcare provider about the best way to feed your baby if you take XANAX XR. The following adverse reactions have been identified during post-approval use of XANAX and/or XANAX XR. Limit dosages and durations to the minimum required. These symptoms may reflect the development of tolerance or a time interval between doses which is longer than the duration of clinical action of the administered dose. What is the most important information I should know about XANAX XR? A high-fat meal given up to 2 hours before dosing with XANAX XR increased the mean Cmax by about 25%. 1 line going down the center of the 2. Administer XANAX XR orally once daily, preferably in the morning. Drugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3)]. The apparent volume of distribution of alprazolam is similar for XANAX XR and XANAX. BioNTech and Pfizer have advance purchase agreements of about US$3billion to provide a licensed vaccine in the United States, the European Union, the United Kingdom, Japan, Canada, Peru, Singapore and Mexico. Inform patients that the use of XANAX XR, even at recommended dosages, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose and death, especially when used in combination with other medications (e.g., opioid analgesics), alcohol, and/or illicit substances. There is positive evidence of human fetal risk during pregnancy. asthma or other breathing disorder; The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. Protect from light. A theme like yours with a few simple tweeks would really make my blog jump Other common Xanax side effects include: Difficulty speaking Problems with coordination The mean absolute bioavailability of alprazolam following administration of XANAX XR is approximately 90%, and the relative bioavailability compared to XANAX is about 100%. The following adverse reactions have occurred with benzodiazepine abuse and/or misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo. if you are also taking itraconazole or ketoconazole; or General disorders and administration site conditions: Reproductive system and breast disorders: Table 4: Clinically Significant Drug Interactions with XANAX XR, Strong Inhibitors of CYP3A (except ritonavir). Early morning anxiety and emergence of anxiety symptoms between doses of XANAX have been reported in patients with panic disorder taking prescribed maintenance doses. Important warnings Alprazolam is a 1,4 benzodiazepine. Preston Mcelheney (, The use of benzodiazepines, including XANAX XR, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. XANAX Tablets (alprazolam) are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual [DSM-III-R] diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. Instruct patients that discontinuation or dosage reduction of XANAX XR may require a slow taper [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. Thank you usamedzone for delivering the good product, Great service for getting Xanax delivered from international Carrier Services that dont ship directly to Finland. (, Use with Other CNS Depressants: Produces additive CNS depressant effects. Ava is a sensor bracelet that tracks your vital signs such as skin temperature and pulse to track your health and send real-time data to the platform. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage [see Dosage and Administration (2.3), Warnings and Precautions (5.3)]. The effects of alprazolam on lactation are unknown. Before prescribing XANAX and throughout treatment, assess each patients risk for abuse, misuse, and addiction. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects. An interim analysis of study data showed a potential efficacy of 91.3% in preventing infection within seven days of a second dose. In addition, the 0.5 mg tablet contains FD&C Yellow No. Alprazolam is in a class of medications called benzodiazepines. Xanax is used to treat anxiety disorders and anxiety caused by depression. It may harm them. Users who take Xanax report feeling the following effects: A calming sensation Feelings Physician Prescribing Information and Patient Information on this page may no longer be current. September 30, 2022. General information about the safe and effective use of XANAX XR. Benzodiazepines cross the placenta and may produce respiratory depression and sedation in neonates. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. WebThe street value of Xanax varies depending on location and the dosage of the pill. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. Your email address will not be published. Sorry, you need to enable JavaScript to visit this website. Serious side effects including coma and death have happened in people who have abused or misused benzodiazepines, including XANAX XR. Set id: aa58fff3-c297-49be-838b-599c32ad9835, WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS. Xanax is used in the treatment of anxiety; panic disorder; depression and belongs to the drug class benzodiazepines. WebXANAX XR (ALPRAZOLAM) 2MG PFIZER $150.00 $1,900.00 XANAX XR (ALPRAZOLAM) 2MG MAIN SUBSTANCE : Alpazolam CATEGORY : Benzo MANUFACTURER : Pfizer DOSAGE : 2-4 tabs/day PACKAGE : 2mg/tab 50 tabs Choose an Option Choose an option1 BOTTLE - 50 TABS2 BOTTLES - 100 TABS4 BOTTLES - 200 TABS6 BOTTLES - 300 TABS8 Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). (6.1). However, the carbamazepine dose used in this study was fairly low compared to the recommended doses (10001200 mg per day); the effect at usual carbamazepine doses is unknown. In many of the spontaneous case reports of adverse behavioral effects, patients were receiving other CNS drugs concomitantly and/or were described as having underlying psychiatric conditions. WebXanax Pfizer 2mg. The most common side effects of XANAX XR include: Keep XANAX XR and all medicines out of the reach of children. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Each XANAX XR extended-release tablet, for oral administration, contains 0.5 mg, 1 mg, 2 mg, or 3 mg of alprazolam. Your email address will not be published. (, Known hypersensitivity to alprazolam or other benzodiazepines. XANAX XR U.S. The use of benzodiazepines, including XANAX XR, exposes users to the risks of abuse, misuse, and addiction, which can lead to overdose or death. Monitor neonates exposed to benzodiazepines during pregnancy and labor for signs of sedation, respiratory depression, withdrawal, and feeding problems and manage accordingly [see Warnings and Precautions (5.4)]. There is positive evidence of human fetal risk during pregnancy. Advise patients, their families and caregivers to look for signs of suicidality or worsening depression, and to inform the patient's healthcare provider immediately [see Warnings and Precautions (5.6)]. Each segment is meant to be a single 0.5 mg dose of Xanax. Ketoconazole and itraconazole have been shown in vivo to increase plasma alprazolam concentrations 3.98 fold and 2.70 fold, respectively. Episodes of hypomania and mania have been reported in association with the use of XANAX XR in patients with depression [see Adverse Reactions (6.1)]. Drugs that inhibit this metabolic pathway may have a profound effect on the clearance of alprazolam. Alprazolam exerts its effect for the treatment of panic disorder through binding to the benzodiazepine site of gamma-aminobutyric acid-A (GABAA) receptors in the brain and enhances GABA-mediated synaptic inhibition. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of the following symptoms. Store at controlled room temperature, 20 to 25C (68 to 77F) [see USP]. However, your second dose may be given up to 6 weeks (42 days) after the first dose, if necessary. Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that may include a strong desire to take the drug, difficulties in controlling drug use (e.g., continuing drug use despite harmful consequences, giving a higher priority to drug use than other activities and obligations), and possible tolerance or physical dependence. These highlights do not include all the information needed to use XANAX XR safely and effectively. There have also been reports of withdrawal seizures upon rapid decrease or abrupt discontinuation of Xanax [see Warning and Precautions (5.2), Drug Abuse and Dependence (9.3)]. Following oral administration of XANAX XR in the morning, peak plasma concentration of alprazolam (Cmax) occurs in about 10 hours postdose. It can be used for the short-term relief of symptoms of anxiety, or anxiety linked with depression. Angioedema has been reported, taking strong cytochrome P450 3A (CYP3A) inhibitors (e.g., ketoconazole, itraconazole), except ritonavir, Neonatal Sedation and Withdrawal Syndrome, Risks in Patients with Impaired Respiratory Function, breathing stops (which may lead to the heart stopping). Though Xanax does have legitimate medical uses, some people abuse it or take it recreationally. you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX XR. WebXanax is the single most prescribed psychiatric drug in the United States; belongs to the benzodiazepines group of drugs. Cardiac disorders: Frequent: palpitation; Infrequent: sinus tachycardia, Ear and Labyrinth disorders: Frequent: Vertigo; Infrequent: tinnitus, ear pain, Eye disorders: Frequent: blurred vision; Infrequent: mydriasis, photophobia, Gastrointestinal disorders: Frequent: diarrhea, vomiting, dyspepsia, abdominal pain; Infrequent: dysphagia, salivary hypersecretion, General disorders and administration site conditions: Frequent: malaise, weakness, chest pains; Infrequent: fall, pyrexia, thirst, feeling hot and cold, edema, feeling jittery, sluggishness, asthenia, feeling drunk, chest tightness, increased energy, feeling of relaxation, hangover, loss of control of legs, rigors, Musculoskeletal and connective tissue disorders: Frequent: back pain, muscle cramps, muscle twitching, Nervous system disorders: Frequent: headache, dizziness, tremor; Infrequent: amnesia, clumsiness, syncope, hypotonia, seizures, depressed level of consciousness, sleep apnea syndrome, sleep talking, stupor, Psychiatric system disorders: Frequent: irritability, insomnia, nervousness, derealization, libido increased, restlessness, agitation, depersonalization, nightmare; Infrequent: abnormal dreams, apathy, aggression, anger, bradyphrenia, euphoric mood, logorrhea, mood swings, dysphonia, hallucination, homicidal ideation, mania, hypomania, impulse control, psychomotor retardation, suicidal ideation, Renal and urinary disorders: Frequent: difficulty in micturition; Infrequent: urinary frequency, urinary incontinence, Respiratory, thoracic, and mediastinal disorders: Frequent: nasal congestion, hyperventilation; Infrequent: choking sensation, epistaxis, rhinorrhea, Skin and subcutaneous tissue disorders: Frequent: sweating increased; Infrequent: clamminess, rash, urticaria, Vascular disorders: Infrequent: hypotension, Discontinuation-Emergent Adverse Reactions Occurring at an Incidence of 5% or More Among Patients Treated with XANAX XR. 4 yr. ago Damn, whats up with all the downvotes? Call your doctor for medical advice about side effects. Inform patients that the continued use of XANAX XR may lead to clinically significant physical dependence and that abrupt discontinuation or rapid dosage reduction of XANAX XR may precipitate acute withdrawal reactions, which can be life-threatening. In patients already receiving an opioid analgesic, prescribe a lower initial dose of XANAX XR than indicated in the absence of an opioid and titrate based on clinical response. In addition, the 1 mg and 3 mg tablets contain D & C yellow No. (, Neonatal Sedation and Withdrawal Syndrome (NOWS): Use of XANAX XR during pregnancy can result in neonatal sedation and neonatal withdrawal syndrome. That makes sense tho why no one really has them in that case then. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Get emergency medical help if you have signs of an allergic reaction to Xanax: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This helps to produce a calming effect in your brain. The mean T1/2 of alprazolam was 19.7 hours (range: 5.8 to 65.3 hours) in patients with alcoholic liver disease. the price margin is also affordable and the best part about usamedzone services are their customer support. The company has several blockbuster drugs or products that each generate more than US$1billion in annual revenues. Each segment is meant to be a single 0.5 mg dose of Xanax. The U.S. Alprazolam oral tablet is a prescription drug thats available as the brand-name drugs Alprazolam Intensol, Xanax, or Xanax XR. If an overdose occurs, consult a Certified Poison Control Center at 1-800-222-1222 for the latest recommendations. To make sure Xanax is safe for you, tell your doctor if you have: seizures or epilepsy; For the same reason, patients should be cautioned about the concomitant use of alcohol and other CNS depressant drugs during treatment with XANAX XR [see Drug Interactions (7.1)]. Buy xanax online no prescription, a brand name of alprazolam, Xanax is generally prescribed for anxiety linked with depression, generalized anxiety disorder, and panic disorder. kidney or liver disease (especially alcoholic liver disease); (, Use with Digoxin: Increase the risk of digoxin toxicity. This type of Xanax has XANAX clearly imprinted across the surface. -Trouble breathing Abrupt discontinuation or rapid dosage reduction of XANAX XR after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures), In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Table 1: Adverse Reactions Leading to Discontinuation in 1% of XANAX XR-treated Patients and at least twice the Rate of Placebo-treated Patients in Placebo-Controlled Trials, General disorders/administration site conditions, Table 2: Adverse Reactions Occuring in 1% in XANAX-treated Patients and Greater than Placebo-treated Patients in 6 and 8 week Placebo-Controlled Trials Panic Disorder, Injury, poisoning, and procedural complications, Musculoskeletal and connective tissue disorder, Respiratory, thoracic, and mediatinal disorders, General disorders and administration site conditions, Musculoskeletal and connective tissue disorders, Respiratory, thoracic, and mediastinal disorders, Table 3: Discontinuation-Emergent Symptom Incidence Reported in 5% of XANAX XR-treated Patients and at least twice the Rate of Placebo-treated Patients in Short-Term, Placebo-Controlled Trials, Respiratory, thoracic and mediastinal disorders, Musculosketal and connective tissue disorders. The mean T1/2 of alprazolam was 21.8 hours (range: 9.9 to 40.4 hours) in a group of obese subjects. Physical dependence is not the same as drug addiction. Reports of serious side effects, such as allergic reactions, are very rare; no long-term complications have been reported. Table 2 shows the incidence of adverse reactions that occurred during 6- and 8-week placebo-controlled trials in 1% or more of patients treated with XANAX XR where the incidence in patients treated with XANAX XR was greater than the incidence in placebo-treated patients. The recommended dosage range is 3 mg to 6 mg once daily. It has been identified that alprazolam 2 mg tablets in bottles of 50 marketed as Xanax have been supplied without child-resistant caps. Pill with imprint XANAX 2 is White Long Bar, Anxiety Disorders. Patients treated with flumazenil should be monitored for re-sedation, respiratory depression, and other residual benzodiazepine effects for an appropriate period after treatment. Consequently, appropriate precautions (e.g., limiting the total prescription size and increased monitoring for suicidal ideation) should be considered in patients with depression. The bioavailability and pharmacokinetics of alprazolam following administration of XANAX XR are similar to that for XANAX, with the exception of a slower rate of absorption. WebThis product information is intended only for residents of the United States. See full prescribing information for complete boxed warning. DESCRIPTION In these studies, patients were treated with XANAX XR in a dose range of 1 mg to 10 mg once per day. Benzodiazepines interact at gamma-aminobutyric acid (GABA, Limit dosage and duration of concomitant use of XANAX XR and opioids, and monitor patients closely for respiratory depression and sedation. Acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. Thanks usamedzone.com for pfizer xanax and for Delivering my pill. Spontaneous reporting system data suggest that the risk of dependence and its severity appear to be greater in patients treated with doses greater than 4 mg/day and for long periods (more than 12 weeks). -Swelling of your face, lips, tongue, or throat. The mean plasma elimination half-life of alprazolam following administration of XANAX XR ranges from 10.7 to 15.8 hours in healthy adults. No, Pfizer Xanax 2mg is still being produced alongside the 0.25 mg, 0.5 mg and 1 mg, tablets. You should not breastfeed while taking XANAX XR. (, Limit dosages and durations to the minimum required. (5.2) Abrupt discontinuation or rapid dosage reduction of XANAX after Buy xanax online no prescription, a brand name of alprazolam, Xanax is generally prescribed for anxiety linked with depression, generalized anxiety disorder, and panic disorder. Do not drive, operate heavy machinery, or do other dangerous activities until you know how XANAX XR affects you. There have been reports of death in patients with severe pulmonary disease shortly after the initiation of treatment with alprazolam. Genocide North America 2025: United States of America (Click the graphic above to view the original archived page) COVID-19 Vaccination in the United States of America (to June 2021) 174,234,573 people This Medication Guide has been approved by the U.S. Food and Drug Administration. narrow-angle glaucoma; (, Effects on Driving and Operating Machinery: Patients receiving XANAX XR should be cautioned against operating machinery or driving a motor vehicle, as well as avoiding concomitant use of alcohol and other central nervous system (CNS) depressant drugs. For the most recent prescribing information, please visit www.pfizer.com. In either case, it is presumed that the prescribed dose is not sufficient to maintain plasma levels above those needed to prevent relapse, rebound, or withdrawal symptoms over the entire course of the interdosing interval. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. In addition, the majority of recent case-control and cohort studies of benzodiazepine use during pregnancy, which were adjusted for confounding exposures to alcohol, tobacco, and other medications, have not confirmed these findings. and the best Part is there customer support. Do not share your XANAX XR with other people. are pregnant or plan to become pregnant. Despite of low prices they are giving best quality FDA approved Drugs. Even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). Its also available as a generic drug. XANAX XR contains alprazolam, which is a Schedule IV controlled substance. Find out more about the street price of Klonopin (Clonazepam) Xanax (Alprazolam) Xanax is one of the most commonly abused benzodiazepines. Analyses of the relationship between treatment outcome and gender did not suggest any differential responsiveness on the basis of gender. Alprazolam oral tablets come in immediate-release and extended-release forms, as well as an orally disintegrating form. 10 and the 2 mg and 3 mg tablets contain FD&C blue No. Isolated published reports involving small numbers of patients have suggested that patients who have borderline personality disorder, a prior history of violent or aggressive behavior, or alcohol or substance abuse may be at risk for such events. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). The mean dose of XANAX XR at the last treatment visit was 4.2 mg per day in the first study and 4.6 mg per day in the second. WebAlprazolam 2mg Xanax Bars 2mg, Pfizer, 50"tab, Treatment: Anxiety,Antidepression 1,500/ Bottle Of 500 mL Get Latest Price Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Some of these can be life-threatening, such as seizures. The dosage of Xanax pills ranges from 0.25 milligrams to 3.5 milligrams. Before prescribing XANAX XR and throughout treatment, assess each patient's risk for abuse, misuse, and addiction, The continued use of benzodiazepines, including XANAX XR, may lead to clinically significant physical dependence. You and your healthcare provider should decide if you should take XANAX XR while you are pregnant. This can cause withdrawal symptoms. Death has been reported in association with overdoses of alprazolam by itself, as it has with other benzodiazepines. Some patients may benefit from an even more gradual discontinuation. Although interactions between benzodiazepines and commonly employed clinical laboratory tests have occasionally been reported, there is no consistent pattern for a specific drug or specific test. 2 mg tablets) may be priced higher. In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months [see Drug Abuse and Dependence (9.3)]. To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Reduce the digoxin dose if necessary. WebThis product information is intended only for residents of the United States. The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and -hydroxyalprazolam) were similar for XANAX and XANAX XR, indicating that the metabolism of alprazolam is not affected by absorption rate. Misuse is the intentional use, for therapeutic purposes, of a drug by an individual in a way other than prescribed by a health care provider or for whom it was not prescribed. The vaccine is given by intramuscular injection. Manifestations of alprazolam overdosage include somnolence, confusion, impaired coordination, diminished reflexes, and coma. 2 mg tablets) may be priced higher. In addition, fatalities have been reported in patients who have overdosed with a combination of a single benzodiazepine, including alprazolam, and alcohol; alcohol levels seen in some of these patients have been lower than those usually associated with alcohol-induced fatality.